Journal
JOURNAL OF INFECTIOUS DISEASES
Volume 201, Issue 3, Pages 336-340Publisher
UNIV CHICAGO PRESS
DOI: 10.1086/649899
Keywords
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Categories
Funding
- Dana Foundation [DF3857-41880]
- National Institutes of Health [1K23MH081786]
- HIV Neurobehavioral Research Center [P30 MH62512]
- University of California, San Diego Center for AIDS Research
- [NS-36722]
- [NS-42069]
- [AI36214]
- [AI29164]
- [AI47745]
- [AI57167]
- [AI55276]
- [MH62512]
- [MH22005]
- [AI47033]
- [AI27670]
- [AI43638]
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We investigated the interactions between human immunodeficiency virus (HIV) infection and aging and their effects on brain function demands by means of functional magnetic resonance imaging (fMRI). A multiple-regression model was used to study the association and interaction between fMRI measures, HIV serostatus, and age for 26 HIV-infected subjects and 25 seronegative subjects. Although HIV serostatus and age independently affected fMRI measures, no interaction occurred. Functional brain demands in HIV-positive subjects were equivalent to those of HIV-negative subjects who were 15-20 years older. Frailty parallels between HIV infection and aging could result from continued immunological challenges depleting resources and triggering increased metabolic demands. In the future, fMRI could be a noninvasive biomarker to assess HIV infection in the brain.
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