Journal
JOURNAL OF INFECTIOUS DISEASES
Volume 202, Issue 4, Pages 633-637Publisher
OXFORD UNIV PRESS INC
DOI: 10.1086/654813
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Funding
- National Institutes of Health [AI60507, AI33774-11, HL59842-07, AI33142-11, AI52733-02, GM 07142-01]
- Fighting Children's Cancers Foundation
- European Commission
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Radioimmunotherapy (RIT) prolongs the survival of mice infected with Cryptococcus neoformans. To compare the efficacy of RIT with that of amphotericin B, we infected AJ/Cr mice intravenously with either nonmelanized or melanized C. neoformans cells. Infected mice were either left untreated or treated 24 h after infection with Bi-213-18B7 antibody, amphotericin B, or both. Melanization before infection did not increase resistance of C. neoformans to RIT in vivo. Bi-213-18B7 treatment almost completely eliminated colony-forming units from the lung and brain, whereas amphotericin B did not decrease the number of colony-forming units. We conclude that RIT is more effective than amphotericin B against systemic infection with C. neoformans.
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