Journal
JOURNAL OF INFECTIOUS DISEASES
Volume 202, Issue 11, Pages 1634-1638Publisher
OXFORD UNIV PRESS INC
DOI: 10.1086/657084
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Funding
- National Institute of Allergy and Infectious Diseases [HHSN266200700005C, R01 AI68265]
- Canadian Institutes of Health Research
- American Lebanese Syrian Associated Charities
- GlaxoSmithKline
- University of Connecticut Health Center
- Vancouver Coastal Health Research Institute
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Levels of preexisting antibodies to the hemagglutinin of pandemic influenza A(H1N1) 2009 (hereafter pandemic H1N1) virus positively correlate with age. The impact of contemporary seasonal influenza vaccines on establishing immunity to other pandemic H1N1 proteins is unknown. We measured serum antibodies to the neuraminidase (NA) of pandemic H1N1 in adults prior to and after vaccination with seasonal trivalent inactivated influenza vaccines. Serum antibodies to pandemic H1N1 NA were observed in all age groups; however, vaccination elevated levels of pandemic H1N1 NA antibodies predominately in elderly individuals (age, >= 60 years). Therefore, contemporary seasonal vaccines likely contribute to reduction of pandemic H1N1-associated disease in older individuals.
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