Journal
JOURNAL OF INFECTIOUS DISEASES
Volume 202, Issue 3, Pages 355-361Publisher
OXFORD UNIV PRESS INC
DOI: 10.1086/653704
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Funding
- Wyeth Vaccines and Pediatrics
- National Institute of Allergy and Infectious Diseases (NIAID) of the US National Institutes for Health (NIH) [U19 AI53217]
- NIAID, NIH, Department of Health and Human Services [HHSN272200800014C]
- Wyeth
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Serotype-specific antibody concentration and opsonophagocytic activity (OPA) were evaluated after 3 doses of pneumococcal conjugate vaccine. Groups included human immunodeficiency virus (HIV)-positive infants with CD4(+) cell percentages >= 25% who initiated immediate antiretroviral treatment (the HIV+/ART+ group) or whose antiretroviral treatment was deferred until clinically or immunologically indicated (the HIV+/ART- group). Immune responses were also evaluated in HIV-noninfected infants born to HIV-seronegative (M-/I-) or HIV-positive mothers (M+/I-). Antibody concentrations were similar between HIV+/ART+ and HIV+/ART- infants. However, antibody concentrations were lower in M/I- infants than in M+/I- infants. Nevertheless, M-/I- infants had superior OPA responses, compared with those in HIV+/ART+ infants, who in turn had better OPA responses, compared with those in HIV+/ART- infants.
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