Journal
JOURNAL OF INFECTIOUS DISEASES
Volume 201, Issue 4, Pages 553-557Publisher
OXFORD UNIV PRESS INC
DOI: 10.1086/650311
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Funding
- Netherlands Foundation for Advancement of Tropical Research (NWO-WOTRO) [WB 93-419]
- Riset Unggulan Terpadu Internasional [149B-3/SK/RUTI/2002]
- Indonesian Ministry of Research and Technology
- Organization for Health Research and Development
- European Union [037919]
- National Institute for Public Health and the Environment
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Animal studies have shown that the globally emerging Beijing genotype strains of Mycobacterium tuberculosis are more virulent than other strains. We examined whether Beijing strains increase treatment failure in a prospective cohort study in Indonesia. Among 818 tuberculosis cases, positive sputum culture results after 6 months of treatment were more common among patients infected with Beijing strains (33.4%) than among those infected with non-Beijing strains (relative risk, 1.94 [95% confidence interval, 1.26-3.00]), even after adjustment for differences in drug resistance. These data suggest that M. tuberculosis Beijing genotype strains have a higher capacity to withstand tuberculosis treatment, even in the absence of drug resistance.
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