Journal
JOURNAL OF INFECTIOUS DISEASES
Volume 202, Issue 1, Pages 109-112Publisher
OXFORD UNIV PRESS INC
DOI: 10.1086/653211
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Funding
- Australian National Health and Medical Research Council (NHMRC ICRG) [283321]
- Wellcome Trust (ICRG) [GR071614MA, 074637]
- Tudor Foundation
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Pathogenic mechanisms underlying vivax malaria are poorly understood, with few studies comparing endothelial and inflammatory responses with falciparum malaria. In adults with uncomplicated vivax or falciparum malaria, we compared plasma measurements of endothelial Weibel-Palade body release (angiopoietin-2) and activation (ICAM-1, E-selectin), as well as selected cytokines. Despite a lower median parasite count, angiopoietin-2 concentrations were higher in patients with vivax malaria, compared with falciparum malaria. Per peripheral parasite, median plasma angiopoietin-2, ICAM-1, E-selectin, interleukin-6, and interleukin-10 concentrations were higher in patients with malaria due to Plasmodium vivax. P. vivax induces greater endothelial Weibel-Palade body release and activation and greater host inflammatory responses, compared with Plasmodium falciparum.
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