Journal
JOURNAL OF INFECTIOUS DISEASES
Volume 202, Issue 12, Pages 1813-1818Publisher
OXFORD UNIV PRESS INC
DOI: 10.1086/657418
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Funding
- Gene Pool Characteristic According to the Polymorphism in Genes of Susceptibility/Resistance to Infectious Diseases within Russian Academy of Sciences program Biodiversity and Dynamics of Gene Pools [11.6]
- National Center for Infectious Diseases, Centers for Disease Control and Prevention [CI000216]
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The 2'-5'-oligoadenylate synthetase (2'-5'-OAS) family members are interferon-induced antiviral proteins. Twenty-three single nucleotide polymorphisms located within the OAS1, OAS2, OAS3, and OASL genes were analyzed in 142 patients with Russian tick-borne encephalitis. Statistically significant differences in genotype, allele, and haplotype frequencies for 3 OAS2 single nucleotide polymorphisms (rs1293762, rs15895, and rs1732778) and 2 OAS3 single nucleotide polymorphisms (rs2285932 and rs2072136) were detected between patients with central nervous system disease and both those with fever and/or meningitis and the control group. The data suggest a possible association between these 5 OAS single nucleotide polymorphisms and the outcome of tick-borne encephalitis virus infection in a Russian population.
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