Journal
JOURNAL OF INFECTIOUS DISEASES
Volume 202, Issue -, Pages S356-S360Publisher
OXFORD UNIV PRESS INC
DOI: 10.1086/655966
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Funding
- Canadian Institutes for Health Research [HVI 79515]
- Fonds de la Recherche en Sante du Quebec AIDS and Infectious Diseases Network
- Canadian Institutes of Health Research
- Bill and Melinda Gates Foundation
- University of Manitoba
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Several combinations of genes encoding KIR3DL1 alleles and their HLA-Bw4 ligands have been linked with favorable outcomes upon exposure to or infection with human immunodeficiency virus (HIV). Some protective KIR3DL1/HLA-Bw4 combinations confer elevated natural killer (NK) cell functional potential. The K562-stimulated functionality of NK cells from KIR3DL1*004/HLA-Bw4 and control genotype carriers was assessed by flow cytometry and found to be higher in KIR3DL1*004/HLA-Bw4 carriers. However, a comparison of the frequency of this combined genotype among HIV-exposed uninfected and HIV-infected subjects revealed no between-group differences. Thus, despite its ability to license NK cells, KIR3DL1*004/HLA-Bw4 is not associated with a reduced risk of infection.
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