Journal
JOURNAL OF INFECTIOUS DISEASES
Volume 201, Issue 3, Pages 331-335Publisher
OXFORD UNIV PRESS INC
DOI: 10.1086/649840
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Funding
- Spanish AIDS Research Network of Excellence [RD06/0006/0021]
- Fundacion para la Investigacion y la Prevencion del SIDA en Espana [366884/07]
- Fondos de Investigacion Sanitaria [CP07/00240, PI081030]
- Consejeria de Salud of Junta de Andalucia [PI0287/2008]
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The most commonly used regulatory T cell (Treg) phenotypes, CD4(+)CD25(hi)CD127(lo) and CD4(+)CD25(hi)FoxP3(+), were simultaneously used to determine the Treg frequency in 2 different groups of human immunodeficiency virus (HIV)-infected persons, one viremic and other aviremic. As expected, a strong correlation between both Treg phenotypes was observed in the aviremic group (r = 0.913; P < .001), but surprisingly, this correlation was completely absent in the viremic group (r = 0.143; P = .572). Data on T cell activation levels of both HIV groups suggest that the CD4(+)CD25(hi)CD127(lo) phenotype could just be mirroring the elevated numbers of activated non-regulatory T cells in the viremic HIV group.
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