Journal
JOURNAL OF INFECTIOUS DISEASES
Volume 199, Issue 10, Pages 1525-1527Publisher
OXFORD UNIV PRESS INC
DOI: 10.1086/598685
Keywords
-
Categories
Funding
- NCRR NIH HHS [P51 RR000164] Funding Source: Medline
- NIAID NIH HHS [P01 AI051649, AI-51649] Funding Source: Medline
Ask authors/readers for more resources
Effective strategies for preventing human immunodeficiency virus infection are urgently needed, but recent failures in key clinical trials of vaccines and microbicides highlight the need for new approaches validated in relevant animal models. Here, we show that 2 new chemokine (C-C motif) receptor 5 inhibitors, 5P12-RANTES (regulated on activation, normal T cell expressed and secreted) and 6P4-RANTES, fully protect against infection in the rhesus vaginal challenge model. These highly potent molecules, which are amenable to low-cost production, represent promising new additions to the microbicides pipeline.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available