Journal
JOURNAL OF INFECTIOUS DISEASES
Volume 198, Issue 4, Pages 571-575Publisher
OXFORD UNIV PRESS INC
DOI: 10.1086/590210
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Funding
- NHLBI NIH HHS [HL077096, P50 HL077096] Funding Source: Medline
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Staphylococcus aureus is a leading cause of ventricular assist device-related infections. This study evaluated the protective effect against S. aureus infection of active and passive immunization that targeted 3 proteins involved in bacterial attachment to a murine intra-aortic polyurethane patch. Active immunization of mice with a combination of the A domains of clumping factor A (ClfA), fibronectin-binding protein A (FnBPA) and fibronectin-binding protein B or passive immunization with monoclonal antibodies against ClfA and FnBPA resulted in a higher level of protection than that obtained by vaccination with either protein or antibody alone. The combination of antibodies or protein antigens appears to provide enhanced protection against prosthetic-device infection.
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