Journal
JOURNAL OF INFECTIOUS DISEASES
Volume 197, Issue 10, Pages 1402-1407Publisher
UNIV CHICAGO PRESS
DOI: 10.1086/587696
Keywords
-
Categories
Funding
- NCRR NIH HHS [M01 RR000079, M01-RR-00079, M01 RR000071, M01-RR-00083, M01-RR-00071, M01 RR000083] Funding Source: Medline
- NIAID NIH HHS [U01-AI-34993, R56 AI052065, U01 AI035004, U01 AI034994, U01 AI042590, U01 AI031834, U01-AI-34989, U01 AI034989, U01-AI-35004, R01 AI052065, U01 AI034993, U01-AI-31834, R01 AI052065-03, R01 AI052065-01, U01-AI-42590, R01 AI052065-02, U01-AI-34994, R01 AI052065-04] Funding Source: Medline
- OID CDC HHS [U01-CH-32632] Funding Source: Medline
Ask authors/readers for more resources
Immuneactivation is a hallmark ofhumanimmunodeficiency virus type 1 (HIV-1) infection and impacts innate and adaptive immunity. Individuals coinfected with HIV-1 and hepatitis C virus (HCV) may have increased immune activation early in HIVdisease because of a highHCVantigen load in tissues such as the liver. WeevaluatedTcell markers of activation and maturation in women with or without HIV-1 infection, by HCV antibody and HCV RNA status. We found increased percentages of activated CD8(+) T cells (i. e., CD8(+) HLA-DR+ 38(+) cells and CD8(+) CD28(+) HLA-DR+ cells) but not of CD4(+) T cells among women who tested positive for HIV-1, HCV antibody, and HCV RNA, compared with HIV-1-positive women who tested negative forHCVantibody. Because CD8(+) T cell activation is related to HIV-1 disease progression, these data may have implications for the medical management of patients coinfected with HIV-1 and HCV.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available