Journal
JOURNAL OF INFECTIOUS DISEASES
Volume 197, Issue 4, Pages 544-547Publisher
OXFORD UNIV PRESS INC
DOI: 10.1086/526793
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Funding
- FIC NIH HHS [D43 TW007129, D43 TW007129-05, D43 TW007129-08, D43TW007129] Funding Source: Medline
- NHLBI NIH HHS [R01 HL073732-05A1, R01 HL073732-08, R01 HL073732, R01-HL073732, R01 HL073732-01] Funding Source: Medline
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Chronic chagasic cardiomyopathy, which is caused by the protozoan Trypanosoma cruzi, is a major cause of heart failure in Latin America. It is a disease for which effective treatment in its advanced clinical forms is lacking. We have previously shown that bone marrow mononuclear cell (BMC) transplantation is effective in reducing inflammation and fibrosis in the mouse model of Chagas disease. The present study used magnetic resonance imaging to assess changes in the cardiac morphology of infected mice after therapy with BMCs. Serial imaging of the BMC-treated mice revealed regression of the right ventricular dilatation typically observed in the chagasic mouse model.
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