Journal
JOURNAL OF INFECTIOUS DISEASES
Volume 197, Issue 12, Pages 1695-1700Publisher
UNIV CHICAGO PRESS
DOI: 10.1086/588671
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Funding
- Intramural NIH HHS [Z01 AI000370-25, Z99 AI999999] Funding Source: Medline
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Simian immunodeficiency virus-infected macaques may develop encephalitis, a feature more commonly observed in macaques with rapid progressive disease than in those with conventional disease. In this report, an analysis of 2 conventional progressors with encephalitis is described. Phylogenetic analyses of viruses isolated from the cerebrospinal fluid and plasma of both macaques demonstrated compartmentalization. Furthermore, these viruses appear to have undergone adaptive evolution to preferentially replicate in their respective cell targets of monocyte-derived macrophages and peripheral blood mononuclear cells. A statistically significant loss of potential N-linked glycosylation sites in glycoprotein 160 was observed in viruses isolated from the central nervous system.
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