Journal
JOURNAL OF INFECTIOUS DISEASES
Volume 197, Issue 2, Pages 266-269Publisher
OXFORD UNIV PRESS INC
DOI: 10.1086/524709
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Tickborne encephalitis (TBE) virus infections can be asymptomatic or cause moderate to severe injuries of the central nervous system. Why some individuals develop severe disease is unknown, but a role for host genetic factors has been suggested. To investigate whether chemokine receptor CCR5 is associated with TBE, CCR5 Delta 32 genotyping was performed among Lithuanian patients with TBE (n = 129) or with aseptic meningoencephalitis (n = 76) as well as among control subjects (n = 134). We found individuals homozygous for CCR5 Delta 32 (P = .026) only among patients with TBE and a higher allele prevalence among patients with TBE compared with the other groups studied. CCR5 Delta 32 allele prevalence also increased with the clinical severity of disease.
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