Journal
JOURNAL OF INFECTIOUS DISEASES
Volume 197, Issue 4, Pages 618-621Publisher
OXFORD UNIV PRESS INC
DOI: 10.1086/526500
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Funding
- Fundação para a Ciência e a Tecnologia [POCI/SAU-ESP/61080/2004] Funding Source: FCT
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Toll-like receptors (TLRs) are important components of innate immunity. We investigated the association between polymorphisms in the TLR2, TLR4, and TLR9 genes and susceptibility to noninvasive forms of pulmonary aspergillosis. A significant association was observed between allele G on Asp299Gly (TLR4) and chronic cavitary pulmonary aspergillosis (odds ratio [OR], 3.46;P = .003). Susceptibility to allergic bronchopulmonary aspergillosis was associated with allele C on T-1237C (TLR9) (OR, 2.49; P = .043). No particular polymorphism was associated with severe asthma with fungal sensitization. These findings reinforce the importance of innate immunity in the pathogenesis of different forms of aspergillosis.
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