Journal
JOURNAL OF INFECTIOUS DISEASES
Volume 197, Issue 7, Pages 1011-1015Publisher
UNIV CHICAGO PRESS
DOI: 10.1086/529206
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Funding
- NCRR NIH HHS [5-M01-RR-00722, M01 RR000722] Funding Source: Medline
- NIAID NIH HHS [P01-AI57005, R01 AI047734, U01-AI-37613, U01-AI-35042, U01 AI035042, U01 AI035040, R01-AI058894, U01 AI035039, U01 AI037984, U01-AI-35043, U01 AI037613, U01-AI-35041, R01 AI058894-04, P01 AI057005, U01-AI-35040, P30-AI27757, U01-AI-37984, R01 AI047734-05, U01 AI035043, P30 AI027757, U01-AI-35039, R37-AI047734, U01 AI035041, R37 AI047734, R37 AI047734-06A1, R01 AI058894] Funding Source: Medline
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Understanding the characteristics of human immunodeficiency virus ( HIV) necessary for infection in a new host is a critical goal for acquired immunodeficiency syndrome ( AIDS) research. We studied the characteristics of HIV-1 envelope genes in 38 men in the Multicenter AIDS Cohort Study cohort before seroconversion. We found a range of diversity ( 0.2%-5.6% [ median, 0.86%]), V1-V2 loop length ( 58-93 aa), and potential N-linked glycosylation sites ( n = 2-9). However, at least 46% of the men had replicating virus that appeared to have been derived from a single viral variant. Nearly all variants were predicted to be CCR5 tropic. We found no correlation between these viral characteristics and the HIV outcomes of time to clinical AIDS or death and/or a CD4 cell count < 200 cells/mu L.
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