Journal
JOURNAL OF INFECTION AND CHEMOTHERAPY
Volume 19, Issue 4, Pages 571-578Publisher
ELSEVIER SCIENCE BV
DOI: 10.1007/s10156-013-0637-2
Keywords
Neisseria gonorrhoeae; Nationwide surveillance; Antimicrobial susceptibilities; Japan
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Funding
- Kyorin Pharmaceutical
- Shionogi Co. Ltd.
- Taisho Pharmaceutical
- Toyama Chemical
- Daiichi-Sankyo
- Dainippon Sumitomo Pharma
- Taiho Pharma
- Meiji Seika Pharma
- Meiji Seika Pharma Co., Ltd.
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Neisseria gonorrhoeae is one of the most important pathogens causing sexually transmitted infection, and strains that are resistant to several antimicrobials are increasing. To investigate the trends of antimicrobial susceptibility among N. gonorrhoeae strains isolated from male patients with urethritis, a Japanese surveillance committee conducted the first nationwide surveillance. The urethral discharge was collected from male patients with urethritis at 51 medical facilities from April 2009 to October 2010. Of the 156 specimens, 83 N. gonorrhoeae strains were tested for susceptibility to 18 antimicrobial agents. The prevalence of beta-lactamase-producing strains and chromosomally mediated resistant strains were 7.2 % and 16.5 %, respectively. None of the strains was resistant to ceftriaxone, but the minimum inhibitory concentration (MIC) of ceftriaxone for 7 strains (8.4 %) was 0.125 mu g/ml. One strain was resistant to cefixime (MIC 0.5 mu g/ml). The MICs of fluoroquinolones, such as ciprofloxacin, levofloxacin, and tosufloxacin, showed a bimodal distribution. The MIC of sitafloxacin was lower than those of the three fluoroquinolones listed here, and it was found that the antimicrobial activity of sitafloxacin was stronger than that of the fluoroquinolones. The MIC of azithromycin in 2 strains was 2 mu g/ml, but no high-level resistance to macrolides was detected.
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