Journal
JOURNAL OF INFECTION AND CHEMOTHERAPY
Volume 15, Issue 6, Pages 417-419Publisher
SPRINGER TOKYO
DOI: 10.1007/s10156-009-0727-3
Keywords
Methicillin-resistant Staphylococcus aureus; Linezolid-resistant MRSA
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Funding
- Pfizer Japan
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We report a 54-year-old male patient with an infection caused by linezolid-resistant methicillin-resistant Staphylococcus aureus (MRSA), isolated after long-term, repeated use of linezolid. Five MRSA strains isolated from our patient were preserved and submitted to bacteriological analysis. All five of these strains were found to have identical genotypes by pulsed-field gel electrophoresis. Two strains isolated in the early hospital period were sensitive to linezolid, while three isolated in the late hospital period were resistant. These three strains that had acquired resistance to linezolid were found to have a G2576T point mutation in the 23SrRNA domain V. Linezolid-resistant MRSA is rare, but may occur with the long-term, repeated administration of linezolid.
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