Journal
JOURNAL OF INFECTION
Volume 66, Issue 5, Pages 391-400Publisher
W B SAUNDERS CO LTD
DOI: 10.1016/j.jinf.2012.10.026
Keywords
HIV; Diversity; Subtype; Recombinant; Vaccine; CRF
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Funding
- National Institute of Health Research, United Kingdom
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HIV-1 genetic variability within individuals and populations plays a central role in the HIV pandemic. Multiple zoonotic transmissions of SIV to humans have resulted in distinct HIV lineages in humans which have further diversified within the population over time. High rates of mutation and recombination during HIV reverse transcription create a genetic diversity in the host which is subject to selection pressures by the immune response and antiretroviral treatment. The global distribution of HIV genetic variants and the impact of HIV diversity on pathogenesis, transmission and clinical management are reviewed. Finally, the key role of escape mutations in the immune response to HIV is discussed as well as the major challenge which HIV-1 diversity poses to HIV vaccine development. Crown Copyright (C) 2012 Published by Elsevier Ltd on behalf of The British Infection Association. All rights reserved.
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