Journal
JOURNAL OF INFECTION
Volume 64, Issue 5, Pages 449-477Publisher
W B SAUNDERS CO LTD
DOI: 10.1016/j.jinf.2011.11.013
Keywords
Encephalitis; Viral encephalitis; Herpes simplex virus; Immunocompromised; Varicella zoster virus; Enterovirus; Antibody-associated encephalitis
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Funding
- Medical Research Council [G116/194] Funding Source: Medline
- Department of Health [DRF-2010-03-97, RP-PG-0108-10048] Funding Source: Medline
- MRC [G116/194] Funding Source: UKRI
- Medical Research Council [G116/194] Funding Source: researchfish
- National Institute for Health Research [RP-PG-0108-10048] Funding Source: researchfish
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In the 1980s the outcome of patients with herpes simplex encephalitis was shown to be dramatically improved with aciclovir treatment. Delays in starting treatment, particularly beyond 48 h after hospital admission, are associated with a worse prognosis. Several comprehensive reviews of the investigation and management of encephalitis have been published. However, their impact on day-to-day clinical practice appears to be limited. The emergency management of meningitis in children and adults was revolutionised by the introduction of a simple algorithm as part of management guidelines. In February 2008 a group of clinicians met in Liverpool to begin the development process for clinical care guidelines based around a similar simple algorithm, supported by an evidence base, whose implementation is hoped would improve the management of patients with suspected encephalitis. (C) 2012 Published by Elsevier Ltd on behalf of The British Infection Association.
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