Journal
JOURNAL OF INFECTION
Volume 57, Issue 1, Pages 82-84Publisher
W B SAUNDERS CO LTD
DOI: 10.1016/j.jinf.2008.01.010
Keywords
Cryptococcus; HIV; breast; immune reconstitution; inflammatory syndrome
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Funding
- MRC [G0700530] Funding Source: UKRI
- Medical Research Council [G0700530] Funding Source: Medline
- Medical Research Council [G0700530] Funding Source: researchfish
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Atypical manifestations of Cryptococcus neoformons disease have been reported in patients with HIV-1 infection as part of the spectrum of the immune reconstitution inflammatory syndrome (IRIS). We describe a cryptococcal breast abscess in a patient presenting after 11 months of highly active antiretroviral therapy (HAART). The arguments for and against the case being a novel manifestation of IRIS are discussed. The potential hazards of using CD4 count as a surrogate marker of IRIS and the danger of misdiagnosing IRIS as failure of HAART are highlighted. (c) 2008 The British Infection Society. Published by Elsevier Ltd. All rights reserved.
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