Journal
JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY
Volume 41, Issue 2, Pages 425-431Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s10295-013-1348-5
Keywords
Actinomycete; Heterologous host; Secondary metabolite; Natural product biosynthesis
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Funding
- Biotechnology and Biological Sciences Research Council [BBS/E/J/00000607, BBS/E/J/0000A227] Funding Source: researchfish
- Biotechnology and Biological Sciences Research Council [BBS/E/J/00000607, BBS/E/J/0000A227] Funding Source: Medline
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Heterologous gene expression is one of the main strategies used to access the full biosynthetic potential of actinomycetes, as well as to study the metabolic pathways of natural product biosynthesis and to create unnatural pathways. Streptomyces coelicolor A3(2) is the most studied member of the actinomycetes, bacteria renowned for their prolific capacity to synthesize a wide range of biologically active specialized metabolites. We review here the use of strains of this species for the heterologous production of structurally diverse actinomycete natural products.
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