Journal
JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY
Volume 41, Issue 2, Pages 175-184Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s10295-013-1389-9
Keywords
Combinatorial biosynthesis; Genome mining; Gifted microbes; Heterologous expression; Lasso peptides; NRPS; PKS; Secondary metabolite; Streptomyces
Categories
Funding
- NIAID NIH HHS [R01 AI087849] Funding Source: Medline
- NIGMS NIH HHS [R01 GM092218] Funding Source: Medline
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Microbial genome mining is a rapidly developing approach to discover new and novel secondary metabolites for drug discovery. Many advances have been made in the past decade to facilitate genome mining, and these are reviewed in this Special Issue of the Journal of Industrial Microbiology and Biotechnology. In this Introductory Review, we discuss the concept of genome mining and why it is important for the revitalization of natural product discovery; what microbes show the most promise for focused genome mining; how microbial genomes can be mined; how genome mining can be leveraged with other technologies; how progress on genome mining can be accelerated; and who should fund future progress in this promising field. We direct interested readers to more focused reviews on the individual topics in this Special Issue for more detailed summaries on the current state-of-the-art.
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