Journal
JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY
Volume 38, Issue 9, Pages 1605-1612Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s10295-011-0952-5
Keywords
Optimized; CO2; Succinic acid; Fermentation; Fixation
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Funding
- National Natural Science Foundation of China [21076105]
- 973 Program of China [2009CB724701]
- Qing Lan Project of Jiangsu province
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The culture conditions in CO2 fixation by Actinobacillus succinogenes for succinic acid production were investigated by a model of available CO2 in a 3-l fermentor. The results from the model analysis showed that the available CO2 for succinic acid production in the fermentation broth is the sum of HCO3 (-), CO3 (2-), and CO2 influenced by external culture conditions such as medium components, CO2 partial pressures, and temperature. The optimized conditions for CO2 supply in a 3-l fermentor were determined as follows: CO2 partial pressure and stirring speed were maintained at 0.1 MPa and 200 r min(-1), respectively, with a pH of 6.8 and a temperature of 37A degrees C; 0.15 mol l(-1) NaHCO3 was added. Under the optimized conditions, a CO2 fixation rate of 0.57 g l(-1) h(-1) was obtained, and a succinic acid concentration of 51.6 g l(-1) with a yield of 75.8% was reached. These results suggest that optimized conditions of CO2 supply are effective in high succinic acid production and thus have potential applications in succinic acid production and CO2 fixation.
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