Supramolecular aminocatalysis via inclusion complex: Amino-doped beta-cyclodextrin as an efficient supramolecular catalyst for the synthesis of chromeno pyrimido[1,2-b]indazol in water

Well-modified amino-appended beta-cyclodextrin (AA-beta-CD) with an amino group at the primary face of the beta-CD was synthesized and used in the catalytic synthesis of chromeno pyrimido(1,2-b]indazol as supramolecular catalysts in water for the first time. AA-beta-CD was characterized by FT-IR, NMR, MALDI-TOF mass spectrometry, and SEM analysis. A possible reaction mechanism featuring molecular complexation was suggested based on 2D NMR (ROESY) spectroscopy, FE-SEM, DSC, and FT-IR. Advantages such as operational simplicity, recyclability of the catalysts, and accessibility in aqueous medium render this protocol eco-friendly. (C) 2018 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved.