Journal
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
Volume 20, Issue 4, Pages 2071-2076Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jiec.2013.09.034
Keywords
Tricyclic antidepressant drugs; SDME; MVPE; Buffer; Voltage; CE
Funding
- National Science Council of Taiwan
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This paper describes the use of single-drop microextraction and micro-volume pipette extraction coupled with capillary electrophoresis for the analysis of five antidepressant drugs (nortriptyline, imipramine, trimeprazine, promethazine, and iminodibenzyl). The five antidepressant drugs are well separated by using micellar electrokinetic capillary chromatography with SDS and organic modifiers. The best extraction was achieved within 10 min and effectively separated within 15 min by using ammonium acetate buffer at 28 kV. This method shows good reproducibility, with RSD values ranging from 4.3 to 8.7%. The LODs values were found to be 0.4 and 1.0 mu g mL(-1) for SDME-CE and 0.15 and 0.5 mu g mL(-1) for MVPE-CE. These methods are simple, rapid, sensitive and efficient for the extraction, separation and detection of tricyclic antidepressant drugs. (C) 2013 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved.
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