Journal
JOURNAL OF IMMUNOLOGY
Volume 201, Issue 6, Pages 1615-1624Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.1800631
Keywords
-
Categories
Funding
- National Institutes of Health [HL123340, DK093668, DK103788, AI121244]
- Howard Hughes Medical Institute
- Stony Wold-Herbert Fund
- Merieux Institute
- Rainin Foundation
- Burroughs Wellcome Fund Investigator in the Pathogenesis of Infectious Diseases award
- Sir Keith Murdoch Fellowship
- Vilcek Fellowship
Ask authors/readers for more resources
The composition of the human microbiome is considered a major source of interindividual variation in immunity and, by extension, susceptibility to diseases. Intestinal bacteria have been the major focus of research. However, diverse communities of viruses that infect microbes and the animal host cohabitate the gastrointestinal tract and collectively constitute the gut virome. Although viruses are typically investigated as pathogens, recent studies highlight a relationship between the host and animal viruses in the gut that is more akin to hostmicrobiome interactions and includes both beneficial and detrimental outcomes for the host. These viruses are likely sources of immune variation, both locally and extraintestinally. In this review, we describe the components of the gut virome, in particular mammalian viruses, and their ability to modulate host responses during homeostasis and disease.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available