Journal
JOURNAL OF IMMUNOLOGY
Volume 194, Issue 1, Pages 21-27Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.1401867
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Funding
- NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES [ZIAAR041159, ZIAAR041106, ZIAAR041167] Funding Source: NIH RePORTER
- Intramural NIH HHS [Z01 AR041106-13] Funding Source: Medline
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More than two decades ago, experiments on the antiviral mechanisms of IFNs led to the discovery of JAKs and their downstream effectors, the STAT proteins. This pathway has since become a paradigm for membraneto-nucleus signaling and explains how a broad range of soluble factors, including cytokines and hormones, mediate their diverse functions. Jak/STAT research has not only impacted basic science, particularly in the context of intercellular communication and cell-extrinsic control of gene expression, it also has become a prototype for transition from bench to bedside, culminating in the development and clinical implementation of pathway-specific therapeutics. This brief review synthesizes our current understanding of Jak/STAT biology while taking stock of the lessons learned and the challenges that lie ahead.
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