Journal
JOURNAL OF IMMUNOLOGY
Volume 192, Issue 9, Pages 4017-4023Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.1302259
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Funding
- Canadian Institutes of Health Research
- Canadian Institutes of Health Research Fellowship award
- Canada Research Chair in Developmental Immunology
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The generation of a functional and diverse repertoire of T cells occurs in the thymus from precursors arriving from the bone marrow. In this article, we introduce the various stages of mouse thymocyte development and highlight recent work using various in vivo, and, where appropriate, in vitro models of T cell development that led to discoveries in the regulation afforded by transcription factors and receptor-ligand signaling pathways in specifying, maintaining, and promoting the T cell lineage and the production of T cells. This review also discusses the role of the thymic microenvironment in providing a niche for the successful development of T cells. In particular, we focus on advances in Notch signaling and developments in Notch ligand interactions in this process.
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