Journal
JOURNAL OF IMMUNOLOGY
Volume 193, Issue 12, Pages 5772-5778Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.1401541
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Funding
- Dutch Science Foundation Netherlands Organisation for Scientific Research [917.66.310]
- National Institutes of Health [AI080564]
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Plasmacytoid dendritic cells (pDC) have been regarded as the professional type I IFN-producing cells of the immune system following viral recognition that relies on the expression of TLR7 and TLR9. Furthermore, pDC link the innate and adaptive immune systems via cytokine production and Ag presentation. More recently, their ability to induce tolerance and cytotoxicity has been added to their immune skills. Such a broad range of actions, resembling the diverse functional features of a Swiss army knife, requires strong and prompt molecular regulation to prevent detrimental effects, including autoimmune pathogenesis or tumor escape. Over the last decades, we and other investigators have started to unravel some aspects of the signaling pathways that regulate the various functions of human pDC. In this article, we review aspects of the molecular regulatory mechanisms to control pDC function in light of their multifaceted roles during immunity, autoimmunity, and cancer.
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