Journal
JOURNAL OF IMMUNOLOGY
Volume 194, Issue 1, Pages 68-75Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.1401653
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Funding
- European Union Seventh Framework Program (FP7) [202063]
- Academy of Finland (Centre of Excellence in Molecular Systems Immunology and Physiology Research) [20122017, 250114]
- Sigrid Juselius Foundation
- Finnish Diabetes Research Foundation
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Upregulation of IL-17 immunity and detrimental effects of IL-17 on human islets have been implicated in human type 1 diabetes. In animal models, the plasticity of Th1/Th17 cells contributes to the development of autoimmune diabetes. In this study, we demonstrate that the upregulation of the IL-17 pathway and Th1/Th17 plasticity in peripheral blood are markers of advanced beta cell autoimmunity and impaired beta cell function in human type 1 diabetes. Activated Th17 immunity was observed in the late stage of preclinical diabetes in children with beta cell autoimmunity and impaired glucose tolerance, but not in children with early beta cell autoimmunity. We found an increased ratio of IFN-gamma/IL-17 expression in Th17 cells in children with advanced beta cell autoimmunity, which correlated with HbA1c and plasma glucose concentrations in an oral glucose tolerance test, and thus impaired beta cell function. Low expression of Helios was seen in Th17 cells, suggesting that Th1/Th17 cells are not converted thymus-derived regulatory T cells. Our results suggest that the development of Th1/Th17 plasticity may serve as a biomarker of disease progression from beta cell autoantibody positivity to type 1 diabetes. These data in human type 1 diabetes emphasize the role of Th1/Th17 plasticity as a potential contributor to tissue destruction in autoimmune conditions.
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