Journal
JOURNAL OF IMMUNOLOGY
Volume 191, Issue 2, Pages 971-981Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.1300280
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Funding
- Council of Scientific and Industrial Research, Government of India, New Delhi [13 (8463-A) 2011]
- Government of India, New Delhi [Indian Council Of Medical Research] [59/6/2011/BMS/TRM]
- Government of India, New Delhi [Council of Scientific and Industrial Research] [37(1524)/12/EMR-II]
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Immune evasion within the tumor microenvironment supports malignant growth and is also a major obstacle for successful immunotherapy. Multiple cellular components and soluble factors coordinate to disrupt protective immune responses. Although stromal cells are well-known for their parenchymal supportive roles in cancer establishment and progression, we demonstrate for the first time, to our knowledge, that tumor-derived vascular pericytes negatively influence CD4(+) T cell activation and proliferation, and promote anergy in recall response to Ag by CD4(+)CD44(+) T cells via regulator of G protein signaling 5- and IL-6-dependent pathways. Our data support a new specific role for tumor-derived pericytes in the immune evasion paradigm within the tumor microenvironment and suggest the targeting of these cell populations in the context of successful immunotherapeutics for the treatment of cancer.
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