Journal
JOURNAL OF IMMUNOLOGY
Volume 190, Issue 7, Pages 3613-3619Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.1202507
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Funding
- National Key Project of 973 [2013CB530504]
- National Natural Science Foundation of China [31230024, 31030029, 31100662, 91029707, 31170868]
- Shanghai Natural Science Foundation Grant [11ZR1442600]
- National Ministry of Science and Technology Grant [2007DFC31700]
- National Science and Technology Major Project [2008ZX10004-002, 2008ZX10002-014, 2009ZX10004-105, 2009ZX10004-016, 2011ZX10004-001, 2012ZX10002007]
- Shanghai Pasteur Health Research Foundation [SPHRF2008001, SPHRF2009001]
- Sanofi-Aventis-Shanghai Institutes for Biological Sciences Discovery Innovation Grant
- Li Kha Shing Foundation
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Virus-induced signaling adaptor (VISA) functions as a critical adaptor in the regulation of both the production of type I IFNs and the subsequent control of the innate antiviral response. In this study, we demonstrate that tripartite motif (Trim)44 interacts with VISA and promotes VISA-mediated antiviral responses. The overexpression of Trim44 enhances the cellular response to viral infection, whereas Trim44 knockdown yields the opposite effect. Trim44 stabilizes VISA by preventing VISA ubiquitination and degradation. These findings suggest that Trim44 functions as a positive regulator of the virus-triggered immune response by enhancing the stability of VISA. The Journal of Immunology, 2013, 190: 3613-3619.
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