Journal
JOURNAL OF IMMUNOLOGY
Volume 191, Issue 5, Pages 2412-2425Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.1300651
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Funding
- Public Health Service [CA78400, AI068836, AI007496, HL007284, GM007267]
- Robert R. Wagner Fellowship
- University of Virginia Cancer Center
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Peripheral tissue homing receptors enable T cells to access inflamed nonlymphoid tissues. In this study, we show that two such molecules, E-selectin ligand and alpha(4)beta(1) integrin, enable activated and memory T cells to enter lymph nodes (LN) as well. This affects the quantitative and qualitative distribution of these cells among regional LN beds. CD8 memory T cells in LN that express these molecules were mostly CD62L(lo) and would normally be classified as effector memory cells. However, similar to central memory cells, they expanded upon Ag re-encounter. This led to differences in the magnitude of the recall response that depended on the route of immunization. These novel cells share properties of both central and effector memory cells and reside in LN based on previously undescribed mechanisms of entry.
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