Journal
JOURNAL OF IMMUNOLOGY
Volume 190, Issue 10, Pages 5118-5127Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.1300114
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Funding
- Fundacao para a Ciencia e a Tecnologia [SFRH/BD/33564/2008, SFRH/BPD/29354/2006]
- Fundação para a Ciência e a Tecnologia [SFRH/BD/33564/2008, SFRH/BPD/29354/2006] Funding Source: FCT
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Development of cerebral malaria (CM), a severe and fatal form of clinical Plasmodium falciparum infection, results from a damaging cascade of vascular, inflammatory, and immunological host responses that leads to brain injury. Progression to CM can be modified by host genetic factors. Our case-control study in Angolan children aimed at highlighting the role of IFN (alpha, beta) receptor 1 (IFNAR1) in progression to CM. We report a robust association between IFNAR1 and CM protection, as well as detailed studies showing analogous protection from experimental CM in Ifnar1(-/-) mice infected with P. berghei ANKA. We developed a novel cell-transfer protocol that enables spleen cell priming in the absence of disease. This led to the discovery that IFNAR1 expression in CD8(+) T cells is crucial and can abrogate resistance to experimental CM in Ifnar1(-/-) mice. Splenic CD8(+) T cells from Ifnar1(-/-) mice are functionally activated upon infection, yet are unable to mediate experimental CM development within the brain tissue. Our findings prove that IFNAR1 signaling unleashes CD8(+) T cell effector capacity, which is vital for CM, and raises the hypothesis that the cohesive role of IFNAR1 in both human and mouse CM operates through CD8(+) T cell triggering.
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