Journal
JOURNAL OF IMMUNOLOGY
Volume 189, Issue 7, Pages 3293-3297Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.1201439
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Funding
- National Institutes of Health [R37 AI38903]
- Predoctoral Training Grant [T32 AI07313]
- Leukemia and Lymphoma Society Career Development Award
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Several recent studies reported that Kruppel-like factor (KLF)2 controls trafficking, development, and function of B cells. Conditional B cell KLF2 knockout mice have increased numbers of marginal zone B cells and decreased numbers of B1 phenoytpe cells. However, it was unclear whether KLF2 is required for B1 B cell development, survival, or phenotypic maintenance. We show that B1 phenotype B cells are present in neonatal mice with B cell-specific KLF2 deficiency, suggesting that B1 differentiation can occur even in the absence of KLF2. Furthermore, by use of an inducible knockout strategy, we show that deletion of KLF2 in mature B1 cells causes loss of phenotypic markers associated with B1 cell identity, but it has a minimal effect on short-term cell survival. Taken together, our findings suggest that KLF2 is necessary for the maintenance of B1 cell identity rather than differentiation or survival of the population. The Journal of Immunology, 2012, 189: 3293-3297.
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