Journal
JOURNAL OF IMMUNOLOGY
Volume 189, Issue 9, Pages 4213-4219Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.1202246
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- National Institute on Aging, National Institutes of Health [AG034113]
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IL-4 has been extensively studied in the context of its role in immunity. Accumulating evidence indicates, however, that it also plays a critical role in higher functions of the normal brain, such as memory and learning. In this review, we summarize current knowledge of the basic immunology of IL-4, describe how and where this cytokine appears to operate in normal brain function, and propose a hypothesis concerning its potential role in neurological pathologies. The Journal of Immunology, 2012, 189: 4213-4219.
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