Journal
JOURNAL OF IMMUNOLOGY
Volume 187, Issue 6, Pages 2841-2847Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.1004006
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Funding
- National Institute of Allergy and Infectious Diseases [R01 AI083988, R01 AI059739]
- National Institutes of Health [T32 CA009149]
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Successful immunity depends upon the activity of multiple cell types. Commitment of pluripotent precursor cells to specific lineages, such as T or B cells, is obviously fundamental to this process. However, it is also becoming clear that continued differentiation and specialization of lymphoid cells is equally important for immune system integrity. Several members of the BTB-ZF family have emerged as critical factors that control development of specific lineages and also of specific effector subsets within these lineages. For example, BTB-ZF genes have been shown to control T cell versus B cell commitment and CD4 versus CD8 lineage commitment. Others, such as PLZF for NKT cells and Bcl-6 for T follicular helper cells, are necessary for the acquisition of effector functions. In this review, we summarize current findings concerning the BTB-ZF family members with a reported role in the immune system. The Journal of Immunology, 2011, 187: 2841-2847.
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