Journal
JOURNAL OF IMMUNOLOGY
Volume 186, Issue 7, Pages 3823-3829Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.1002090
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- National Institutes of Health/National Institute of Allergy and Infectious Diseases [AI051354, AI085568]
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The mechanisms regulating the induction and maintenance of B lymphocytes have been delineated extensively in immunization studies using proteins and hapten-carrier systems. Increasing evidence suggests, however, that the regulation of B cell responses induced by infections is far more complex. In this study, we review the current understanding of B cell responses induced following infection with influenza virus, a small RNA virus that causes the flu. Notably, the rapidly induced, highly protective, and long-lived humoral response to this virus is contributed by multiple B cell subsets, each generating qualitatively distinct respiratory tract and systemic responses. Some B cell subsets provide extensive cross-protection against variants of the ever-mutating virus, and each is regulated by the quality and magnitude of infection-induced innate immune signals. Knowledge gained from the analysis of such highly protective humoral response might provide a blueprint for successful vaccines and vaccination approaches. The Journal of Immunology, 2011, 186: 3823-3829.
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