Journal
JOURNAL OF IMMUNOLOGY
Volume 188, Issue 2, Pages 774-780Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.1101383
Keywords
-
Categories
Funding
- Bundesministerium fur Bildung und Forschung (BMBF) [01 EO 0803]
- Deutsche Forschungsgemeinschaft [SFB 620, He 3127/2-3, He 3127/3-1]
- National Institutes of Health [ROI AI052455-06A1]
Ask authors/readers for more resources
Group B streptococci, a major cause of sepsis, induce inflammatory cytokines in strict dependence on bacterial ssRNA and the host molecules MyD88 and UNC-93B. In this study, we show that NO plays an important role in Group B streptococci-induced transcriptional activation of cytokine genes. Phagocytosis induced NO in a MyD88-dependent fashion. In turn, NO propagated the acidification of phagosomes and the processing of phagosomal bacterial nucleic acids and was required for potent transcriptional activation of cytokine genes by streptococci. This NO-dependent amplification loop has important mechanistic implications for the anti-streptococcal macrophage response and sepsis pathogenesis. The Journal of Immunology, 2012, 188: 774-780.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available