Journal
JOURNAL OF IMMUNOLOGY
Volume 186, Issue 7, Pages 4039-4050Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.1003352
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- Swiss National Science Foundation
- Kanton Basel-Stadt
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Coronins are WD repeat-containing proteins highly conserved in the eukaryotic kingdom implicated in the regulation of F-actin. Mammalian coronin 1, one of the most conserved isoforms expressed in leukocytes, regulates survival of T cells, which has been suggested to be due to its role in preventing F-actin-induced apoptosis. In this study, we come to a different conclusion. We show that coronin 1 does not modulate F-actin and that induction of F-actin failed to induce apoptosis. Instead, coronin 1 was required for providing prosurvival signals, in the absence of which T cells rapidly underwent apoptosis. These results argue against a role for coronin 1 in F-actin-mediated T cell apoptosis and establish coronin 1 as an essential regulator of the balance between prosurvival and proapoptotic signals in naive T cells. The Journal of Immunology, 2011, 186: 4039-4050.
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