Journal
JOURNAL OF IMMUNOLOGY
Volume 187, Issue 10, Pages 4927-4933Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.1100806
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Funding
- Formas, the Swedish Research Council
- King Gustaf V 80-Year Anniversary Fund
- Torsten and Ragnar Soderberg Foundation
- Swedish Cancer Foundation
- Throne Holst Foundation
- South-Eastern Norway Regional Health Authority
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Among the different proteoglycans expressed by mammals, serglycin is in most immune cells the dominating species. A unique property of serglycin is its ability to adopt highly divergent structures, because of glycosylation with variable types of glycosaminoglycans when expressed by different cell types. Recent studies of serglycin-deficient animals have revealed crucial functions for serglycin in a diverse array of immunological processes. However, its exact function varies to a large extent depending on the cellular context of serglycin expression. Based on these findings, serglycin is emerging as a structural and functional chameleon, with radically different properties depending on its exact cellular and immunological context. The Journal of Immunology, 2011, 187: 4927-4933.
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