Journal
ORGANIC PROCESS RESEARCH & DEVELOPMENT
Volume 19, Issue 3, Pages 427-436Publisher
AMER CHEMICAL SOC
DOI: 10.1021/op5003787
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Funding
- Deutsche Bundesstiftung Umwelt (DBU) [AZ 29622-31]
- Slovak Grant Agency VEGA [2/0027/14]
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The influence of crucial reaction parameters on Knoevenagel condensation in planetary ball mills was investigated. Rotation frequency (nu(rot)), milling ball diameter (d(MB)), milling ball filling degree (Phi(MB)), and beaker size had obvious influences on yield. It was found that higher nu(rot), lower d(MB), milling beakers with larger diameter, and a Phi(MB) of similar to 0.3 are advantageous for the reaction. Furthermore, the influence of the type of mill was investigated, including reactions performed in different planetary and mixer ball mills, in a stirred media mill, and with a mortar mill. Comparisons with the other solvent-free synthetic routes showed that ball milling is an effective way of performing the reaction with low energy intensity.
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