Application of Continuous Preferential Crystallization to Efficiently Access Enantiopure Chemicals

Preferential crystallization can be a highly efficient method of producing enantiopure chemicals at large scale. While most preferential crystallization processes have been designed around classical batch crystallizers, numerous advantages can be obtained by incorporating continuous crystallization technologies, allowing better process control and reproducibility with higher material throughput. Even with these marked advantages, continuous preferential crystallization is not utilized as often as a conventional batch process. This review aims to introduce the technique and highlight some examples where continuous preferential crystallization has been employed, emphasizing the advantages in process efficiency.