Journal
JOURNAL OF IMMUNOLOGY
Volume 186, Issue 10, Pages 5758-5765Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.1003043
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Funding
- Centre National de la Recherche Scientifique, University Rene Descartes-Paris V
- Fundacao para a Ciencia e Tecnologia
- Programa Operacional Potencial Humano, Portugal [SFRH/BD/37178/2007, PTDC/SAU-FCF/101017/2008]
- Portugal-France cooperation: Programa Pessoa
- Fundacao para a Ciencia e Tecnologia/Centre National de la Recherche Scientifique
- Fundação para a Ciência e a Tecnologia [SFRH/BD/37178/2007, PTDC/SAU-FCF/101017/2008] Funding Source: FCT
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CD1d-reactive invariant NKT (iNKT) cells have been implicated in a number of experimental models of human pathologies. Given the scope of their immunoregulatory activities mediated through distinct cytokine patterns, it has been proposed that this functional diversity originates from distinct iNKT subpopulations. In this study, we report that human CD161(+) iNKT cells are intrinsically endowed with the capacity to generate IL-17, but require TGF-beta, IL-1 beta, and IL-23 to carry out this potential. IL-17-producing iNKT cells are already present in cord blood but, in contrast to peripheral blood iNKT cells, they cannot generate IFN-gamma. These IL-17 producers respond to aryl hydrocarbon receptor stimulation and express IL-23 receptor and retinoic acid-related orphan receptor C, similar to conventional T helper 17 cells, from which they differ by their restricted ability to coproduce IL-22. In conclusion, IL-17 production by human iNKT cells depends on two critical parameters, namely an intrinsic program and a proinflammatory environment. The Journal of Immunology, 2011, 186: 5758-5765.
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