Journal
JOURNAL OF IMMUNOLOGY
Volume 186, Issue 10, Pages 5603-5611Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.1003464
Keywords
-
Categories
Funding
- University of North Carolina [HD046369]
- National Institutes of Health [AI29564, AI024335, AI007151]
- Cancer Research Institute
Ask authors/readers for more resources
Long-lived humoral immune responses depend upon the generation of memory B cells and long-lived plasma cells during the germinal center (GC) reaction. These memory compartments, characterized by class-switched IgG and high-affinity Abs, are the basis for successful vaccination. We report that a new member of the plexin family of molecules, plexin-D1, controls the GC reaction and is required for secondary humoral immune responses. Plexin-D1 was not required for B cell maturation, marginal zone precursor development, dark and light zone formation, Ig lambda(+) and Ig kappa(+) B cell skewing, B1/B2 development, and the initial extrafollicular response. Plexin-D1 expression was increased following B cell activation, and PlxnD1(-/-) mice exhibited defective GC reactions during T-dependent immune activation. PlxnD1(-/-) B cells showed a defect in migration toward the GC chemokines, CXCL12, CXCL13, and CCL19. Accordingly, PlxnD1(-/-) mice exhibited defective production of IgG1 and IgG2b, but not IgG3 serum Ab, accompanied by reductions in long-lived bone marrow plasmacytes and recall humoral memory responses. These data show a new role for immune plexins in the GC reaction and generation of immunologic memory. The Journal of Immunology, 2011, 186: 5603-5611.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available