Journal
JOURNAL OF IMMUNOLOGY
Volume 184, Issue 9, Pages 4625-4629Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.0903873
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- Biomedical Research Council [SIGN-07-012]
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During priming, CD8(+) T lymphocytes can induce robust maturation of dendritic cells (DCs) in a CD40-independent manner by secreting licensing factor(s). In this study, we isolate this so-far elusive licensing factor and identify it, surprisingly, as GM-CSF. This provides a new face for an old factor with a well-known supporting role in DC development and recruitment. Signaling through the GM-CSFR in ex vivo-purified DCs upregulated the expression of costimulatory molecules more efficiently than did any tested TLR agonist and provided a positive feedback loop in the stimulation of CD8(+) T cell proliferation. Combined with a variety of microbial stimuli, GM-CSF supports the formation of potent effector DCs capable of secreting a variety of proinflammatory cytokines that guide the differentiation of T cells during the immune response. The Journal of Immunology, 2010, 184: 4625-4629.
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