Journal
JOURNAL OF IMMUNOLOGY
Volume 184, Issue 8, Pages 4062-4068Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.0903002
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Funding
- National Institutes of Health [DK50189, DE016191, HL60569]
- Crohn's and Colitis Foundation of America
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Sites of ongoing inflammation and triggered immune responses are characterized by significant changes in metabolic activity. Recent studies have indicated that such shifts in tissue metabolism result from a combination of profound recruitment of inflammatory cells (neutrophils and monocytes) and high proliferation rates among lymphocyte populations. The resultant shifts in energy supply and demand can result in metabolic acidosis and diminished delivery and/or availability of oxygen, leading to hypoxia extensive enough to trigger transcriptional and translation changes in tissue phenotype. Such phenotypic shifts can imprint fundamental changes to tissue metabolism. In this study, we review recent work addressing metabolic changes and metabolic control of inflammation and immunity. The Journal of Immunology, 2010, 184: 4062-4068.
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