Journal
JOURNAL OF IMMUNOLOGY
Volume 185, Issue 11, Pages 6421-6425Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.1002283
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Funding
- European Molecular Biology Organization
- Fundacao para a Ciencia e Tecnologia [PTDC/SAU-MII/104158/2008, PTDC/SAU-MII/099314/2008]
- Wellcome Trust
- Medical Research Council [G0600698B] Funding Source: researchfish
- Fundação para a Ciência e a Tecnologia [PTDC/SAU-MII/104158/2008, PTDC/SAU-MII/099314/2008] Funding Source: FCT
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g delta T lymphocytes are commonly viewed as embracing properties of both adaptive and innate immunity. Contributing to this is their responsiveness to pathogen products, either with or without the involvement of the TCR and its coreceptors. This study clarifies this paradoxical behavior by showing that these two modes of responsiveness are the properties of two discrete sets of murine lymphoid gamma delta T cells. Thus, MyD88 deficiency severely impaired the response to malaria infection of CD27((-)), IL-17A-producing gamma delta T cells, but not of IFN-gamma-producing gamma delta cells. Instead, the latter compartment was severely contracted by ablating CD27, which synergizes with TCR gamma delta in the induction of antiapoptotic mediators and cell cycle-promoting genes in CD27((+)), IFN-gamma-secreting gamma delta T cells. Hence, innate versus adaptive receptors differentially control the peripheral pool sizes of discrete proinflammatory gamma delta T cell subsets during immune responses to infection. The Journal of Immunology, 2010, 185: 6421-6425.
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